Adult:
Initial dose: 100 units SC/IM daily. Maintenance regimen: 50 units SC/IM 3 times wkly to 100 units daily in patients with serious bone deformity or neurologic involvement.
Intravenous
EMERGENCY TREATMENT OF HYPERCALCAEMIA
Adult:5-10 units/kg daily in 500 ml of 0.9% sodium chloride by slow IV infusion over 6 hr.
Parenteral
ADJUNCTIVE TREATMENT FOR HYPERCALCAEMIA
Adult:
100 units every 6-8 hr by SC/IM inj. Adjust dose according to response. In severe cases, IV infusion up to 10 units/kg can be given over 6 hr. Max: 400 units every 6-8 hr.
Parenteral
POSTMENOPAUSAL OSTEOPOROSIS
Adult:
100 units daily or every other day by SC/IM Inj together with calcium and vitamin D supplements.
Parenteral
BONE PAIN DUE TO MALIGNANT NEOPLASMS
Adult:
200 units 4 times daily or 400 units bid for up to 48 hr by SC/IM inj.
Nasal
POSTMENOPAUSAL OSTEOPOROSIS
Adult:
200 units daily, alternating nostrils everyday.
Precautions
Prior intradermal test preferably done. Children <18 yr, renal impairment. Pregnancy, lactation.
Potentially Life-threatening
Adverse Drug Reactions
Nausea, vomiting, tingling of hands; Inj site inflammatory reactions, rashes, facial flushing, bronchospasm, headache, unusual taste, abdominal pain, anorexia. Nasal: Local irritation, ulceration, rhinitis, sinusitis, epistaxis.
Adverse Drug Reactions
Anaphylactic shock.
Interactions
Concurrent use with digitalis, mithramycin, or biphosphonate resorption inhibitors calls for dosage adjustments of these drugs.
